Results – Evaluation of the moisturizing effect (long term) and lenitive (short term)- IN&OUT DETOX®
All 20 subjects completed the study. The demographic characteristics of the sample are shown in table 1. All non-invasive tests were carried out by the same experimenter at an average ambient temperature of 22 ° C and an average relative humidity of 56%. All tests were performed in the morning between 10 am and 2 pm.
| Characteristic | Frequency |
| n | 20 |
| Drop-out | 0 |
| Male | 0 (0%) |
| Female | 20 (100%) |
| White | 20 (100%) |
| Black | 0 |
| Latino | 0 |
| Asian | 0 |
| Age (range) | 23 – 50 |
| Age (mean and SD) | 32,45 ± 8,08 |
EVALUATION OF THE MOISTURIZING EFFICACY
Corneometry
The skin hydration values increase statistically significantly in the Long Term Test (table 2).
| IN & OUT DETOX® | t0 | t7d |
| Corneometric measurement | 42,74 ± 4,81 | 47,3 ± 6,48 |
|
Baseline change from t0 (mean and SD)
|
4,56 ± 7,15 | |
|
Percentage change from t0 (mean)
|
11,5 % | |
| p-value | 0,0102 |
EVALUATION OF LENITIVE EFFICACY
After the application of SDS in occlusion, the active agent was able to reduce the TEWL and erythema after 4 hours from its application (Table 3). No changes were found in the control area compared to baseline.
| IN & OUT DETOX® | t0 | t0 SDS | t2h SDS | t4h SDS |
| TEWL measurement | 11,54 ± 1,08 | 12,65 ± 1,07 | 12,45 ± 0,82 | 11,86 ± 1,08 |
|
Baseline change from t0 (mean and SD)
|
1,11 ± 1,37 | 0,90 ± 1,42 | -0,7 ± 1,48 | |
|
Percentage change from t0 (mean)
|
10,3 % | 8,83 % | -5,68 % | |
| p-value | 0,002 | 0,47 | 0,027 |
| IN & OUT DETOX® | t0 | t0 SDS | t2h SDS | t4h SDS |
| Mexameter E measurement | 220,6 ± 31,9 | 255,0 ± 27,5 | 241,2 ± 21,6 | 233,8 ± 24,2 |
|
Baseline change from t0 (mean and SD)
|
34,4 ± 28,4 | 20,5 ± 34,3 | -21, ± 39,8 | |
|
Percentage change from t0 (mean)
|
17,0 % | 11,1 % | -6,91 % | |
| p-value | 0 | 0,084 | 0,028 |
Tolerability assessment
None of the 20 volunteers had any adverse or allergic adverse reactions.
