URBAN POLLUTION DEFENSE & INNER SKIN LONGEVITY
LongeviTEA® is a next-generation biomimetic active inspired by the adaptive longevity mechanisms of Camellia sinensis grown in the Bama region of China, a low-pollution environment internationally recognized for its exceptional longevity. In this unique ecological context, the plant develops protective strategies to maintain functional balance under long-term environmental stress, resulting in a phytochemical profile naturally rich in catechins and polyphenols with strong redox-regulating capacity. These bioactives are refined through an advanced extraction and purification process designed to preserve molecular integrity and bioactivity.
In urban environments, the skin is continuously exposed to airborne pollutants that generate persistent oxidative pressure and trigger early inflammatory signaling. Over time, this molecular stress progressively weakens barrier function, disrupts cellular balance and accelerates structural aging processes.
By translating the adaptive strategies of Camellia sinensis into skin-relevant biology, LongeviTEA® targets key pollution-driven pathways, including oxidative DNA damage and inflammatory escalation, helping the skin maintain functional homeostasis under continuous environmental exposure.
Through modulation of these upstream mechanisms, LongeviTEA® supports inner skin longevity, reinforcing dermal integrity and contributing to a more resilient, balanced and visibly healthier complexion in daily urban life.
EFFICACY TEST
Pollution-induced oxidative DNA damage mitigation (8-OHdG)
Rationale
Urban pollutants generate excessive reactive oxygen species (ROS) that directly damage cellular DNA. Oxidative DNA lesions accumulate over time, impairing repair mechanisms and accelerating skin aging.
8-hydroxy-2’-deoxyguanosine (8-OHdG) is a well-established endogenous marker of oxidative DNA damage and a relevant indicator of pollution-induced cellular stress.
Model
Human keratinocytes (HaCaT) were exposed to a complex urban dust mixture composed of polycyclic aromatic hydrocarbons, nitro-substituted PAHs, polychlorinated biphenyls, pesticide residues and inorganic particulate matter. Cells were treated with LongeviTEA®.
Outcome
LongeviTEA® significantly reduced 8-OHdG levels compared to polluted controls.
Meaning
By limiting oxidative DNA damage at the cellular level, LongeviTEA® helps preserve genomic integrity and supports early interception of pollution-driven aging pathways
Pollution-induced inflammatory pathway modulation (IL-1α)
Rationale
Pollution exposure rapidly activates inflammatory signaling in keratinocytes. Interleukin-1 alpha (IL-1α) is an early pro-inflammatory cytokine released in response to cellular stress and acts as an upstream trigger for inflammatory cascade amplification, contributing to chronic skin imbalance and sensitivity.
Model
Human keratinocytes exposed to the same complex urban dust mixture were treated with LongeviTEA®. IL-1α release was quantified as a marker of pollution-induced inflammatory activation.
Outcome
LongeviTEA® significantly reduced IL-1α levels, confirming a marked attenuation of early inflammatory signaling.
Meaning
By modulating upstream inflammatory escalation, LongeviTEA® helps prevent the amplification of pollution-induced cellular stress, supporting skin comfort, resilience and long-term functional balance.
INNER SKIN LONGEVITY – STRUCTURAL EFFICACY
Pollution-related dermal density reinforcement
Rationale
Chronic exposure to urban pollution and photopollution accelerates oxidative stress within the dermis, progressively impairing extracellular matrix integrity. This structural damage precedes visible loss of firmness and elasticity, making dermal density a predictive marker of long-term skin aging and longevity.
By intercepting pollution-driven molecular stress upstream, it is possible to preserve dermal architecture before irreversible structural degradation occurs.
Study design
A 56-day split-face, placebo-controlled clinical study was conducted on 20 healthy women aged 35–65, selected for their outdoor lifestyle to reflect chronic environmental exposure.
A cream containing 5% LongeviTEA® was applied once daily and compared with a placebo formulation.
Dermal density was measured at baseline and after 14, 28 and 56 days using high-frequency ultrasound (50 MHz).
Outcome
Treatment with LongeviTEA® resulted in a progressive and significant increase in dermal density, reaching +18.8% after 56 days (p < 0.01 vs baseline).
An early response was already observed at Day 14 (+10.7%), an uncommon feature for botanical-derived actives.
Meaning
These results demonstrate that LongeviTEA® reinforces dermal structure, supporting extracellular matrix integrity and long-term skin firmness under chronic pollution-related stress.
The early onset of efficacy suggests timely interception of pollution-driven pathways involved in structural degradation.
