Actives extractives

in & out DETOX®

Moisturizing, purifying plant-derived anti-pollution complex

moisturizing – purifying – anti sebum

 

INCI name

Polyglycerin-6, Propanediol, Solanum Melongena (Eggplant) Fruit Extract, Bioflavonoids, Brassica Oleracea Italica (Broccoli) Extract

 

 
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In & out DETOX® is a natural active plant complex designed to protect the skin effectively against external and internal stressors. It helps in fighting damages due to pollutants, UV radiations, free radicals and chemicals by getting rid of oxidative stress intermediates.

COMPOSITION

Broccoli (Sulforaphane): Activates Phase 2 detox enzymes, protecting skin against UV radiation, environmental pollutants, and internal reactive molecules (Boddupalli S. et al., 2012).

Bioflavonoids (Nobiletin): Found in citrus peel, exhibits antioxidant, anti-inflammatory, anti-allergic, antitumor, and antiangiogenic properties (Kim E. et al., 2022).

Ethiopian Eggplant (Flavonoids, Polyphenols, Phytosterols): Offers strong antioxidant activity, reduces inflammation and tissue damage, and enhances collagen production and tissue metabolism (Han M. et al., 2021).

Image showing broccoli, lemon, and a red fruit, representing natural ingredients used in cosmetic formulations.

ANTIOXIDANT ACTIVITY

Superoxide dismutase (SOD) is a key enzyme in cells, acting as a powerful antioxidant and part of the defense against harmful reactive oxygen species (ROS), as described by Ighodaro O.M. and Akinloye O.A. in 2018.

In & out DETOX® has been shown to significantly increase SOD2 expression in cells at various concentrations, particularly after 6 and 24 hours of application, and also enhances Catalase expression, highlighting its effectiveness in boosting the body’s natural antioxidant defenses.

Bar charts showing the effect of In & Out Detox® at different concentrations on SOD2 and Catalase activity at 6 hours and 24 hours, compared to untreated and positive control groups.

Clinical evaluation of soothing and lenitive efficacy

Corneometric measurement shows that in & out DETOX® significantly increased skin hydration and its effect is long lasting. In addition, in & out DETOX® significantly improves Trans Epidermal Water Loss (p<0.027 and p<0.028 respectively) and Erythema index in subjects with SDS-induced skin irritation.

Bar charts showing the effect of In & Out Detox® 2% on hydration, Transepidermal Water Loss (TEWL), and erythema measurements at different time points (T0, T1H, T2H, T4H, 7D).

Clinical evaluation of purifying efficacy

2% in & out DETOX® in a detergent, significantly reduces sebometry and skin desquamation thus improving hydrolipidic film and protecting skin barrier. in & out DETOX® shows also pore cleanliness. 

Bar charts showing the effect of In & Out Detox® 2% on sebum levels and desquamation index at different time points (T0, T1H, T4H).
Images showing close-ups of skin texture before and after treatment, highlighting improvements in smoothness and clarity.
  • 100% plant-derived and palm-free.
  • It protects and defends the skin from pollutant substances and environmental stress factors. It activates the enzymes that oversee the detoxification process.
  • Improves pore cleanliness and balance sebum production.
  • Soluble in warm water, ethanol, glycerine and propylene glycol.

 

ORIGIN

Synergistic blend of vegetal active compounds delivered in polyglycerol medium.

 
   Appearance Liquid
   Colour Light yellow
   Odour Characteristic
   pH 5.0 – 7.0
   Dry residue (105°C) 48- 52%
   Specific Gravity (25°C) 1.13 – 1.17

Ideal both for day & night emulsions as well as cleansing milks and transparent toners/micellar waters.
Ideal to be incorporated in non-toxic, completely biodegradable and safe O/W and W/O emulsions as well as transparent water-based applications.

% OF USE: 2.0%

 

 

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