All 20 subjects completed the study. The demographic characteristics of the sample are shown in table 1. All non-invasive tests were carried out by the same experimenter at an average ambient temperature of 21 ° C and an average relative humidity of 57%. All tests were performed in the morning between 10 and 14.

   n = 20
   Drop-out 0
   Male 0 (0%)
   Female 20 (100%)
   Age (range) 20 – 38
   Age (mean and SD) 28,4 ± 4,77

Table 1

Evaluation of the corneometry

The skin hydration values increase statistically significantly in the first 4 hours (table 2).

   IN & OUT DETOX® t0 t1h t4h
   Corneometric measurement 40,43 ± 4,64 43,55 ± 4,72 43,05 ± 3,44
   Baseline change from t0 (mean and SD)
  3,11 ± 5,26 2,61 ± 4,41
   Percentage change from t0 (mean)
  8,58 % 7,39 %
   p-value   0,016 0,016

Table 2

Evaluation of sebometry

Mean sebometry values were reduced, compared to baseline, in the first hour after washing (Table 3).

  IN & OUT DETOX® t0 t1h t4h
   Corneofix measurement 61,6 ± 13,2 45,15 ± 10,5 49,8 ± 11,7
   Baseline change from t0 (mean and SD)
  -16,4 ± 19,5 -11,8 ± 15,6
   Percentage change from t0 (mean)
  -21,8 % -16,4 %
   p-value   0,001 0,002

Table 3

Evaluation of the desquamation index

The desquamation index, after the use of the product, decreases at all times studied (Table 4).

   IN & OUT DETOX® t0 t1h t4h
   Corneofix measurement 61,6 ± 13,2 35,65 ± 8,00 49,8 ± 11,7
   Baseline change from t0 (mean and SD)
  -25,9 ± 17,6 -11,8 ± 15,6
   Percentage change from t0 (mean)
  -38,0 % -16,4 %
   p-value   0,000 0,002

Table 4

Evaluation of tolerability

None of the 20 volunteers had adverse or allergic adverse reactions.