Results – Moisturizing and Protective effectiveness – PG6 Active HYDRA FACTOR

All 20 subjects completed the study. The demographic characteristics of the sample are shown in Table 1.
All the instrumental examinations were carried out in the same clinic, at an average temperature of 23° ± 1.3° and an average humidity of 55% ± 1.7%. The measurements were always carried out by the same experimenter.

   Characteristic Frequency
   n 20
   drop-out 0
   Male 6 (30%)
   Female 14 (70%)
   White 20 (100%)
   Black 0
   Latino 0
   Asian 0
   Age (range) 22 – 52
   Age (mean and SD) 31,85 ± 8,98

Moisturizing effectiveness evaluation

Corneometry

Skin hydration values increase statistically significantly at all times studied in the long term test (Table 2).

   PG6 ACTIVE HYDRA FACTOR®

t0

t4h

t7d

t14d
   Corneometric measurement 38,95 ± 4,81 44,77 ± 8,18 42,73 ± 5,62 43,67 ± 5,35
   Baseline change from t0 (mean and SD)
   5,82 ± 8,80 3,78 ± 7,84 4,72 ± 8,66
   Percentage change from t0 (mean)
   16,2 % 11,5 % 14,4 %
   p-value   0,0081 0,044 0,0249

Soothing effectiveness assessment

After the application of SDS in occlusion the active was able to reduce TEWL and erythema 8 hours after its application (Table 3). No changes to basal were detected in the control area.

   PG6 ACTIVE HYDRA FACTOR® t0 t0 SDS t4h SDS t8h SDS
   TEWL measurement 11,54 ± 1,13 14,16 ± 1,83 13,35 ± 1,51 12,72 ± 1,41
   Baseline change from t0 (mean and SD)
   2,61 ± 2,46 1,80 ± 1,99 -1,4 ± 2,13
   Percentage change from t0 (mean)
   24,4 % 16,8 % -9,02 %
   p-value   0,000 0,153 0,007
   PG6 ACTIVE HYDRA FACTOR® t0 t0 SDS t4h SDS t8h SDS
   Mexameter E measurement 227,0 ± 33,1 322,3 ± 41,8 299,3 ± 33,6 265 ± 37,0
   Baseline change from t0 (mean and SD)
   95,2 ± 53,4 72,2 ± 40,5 -57,3 ± 51,2
   Percentage change from t0 (mean)
   44,8 % 34,0 % -16,7 %
   p-value   0,000 0,010 0,000

Tolerability assessment

None of the 20 volunteers had any adverse irritative or allergic reactions.