RESULTS

The 20 subjects completed the study. The demographic characteristics of the 2 samples are shown in table 1. All the non-invasive tests were carried out by the same experimenter, between the ages of 9 and 14, at an average ambient temperature of 23 ° C and an average relative humidity of 56%.

DEMOGRAPHICS
 Characteristic Frequency
  n   20
  drop-out   0
  Male   0 (0%)
  Female   20 (100%)
  White   20 (100%) 0
  Black   0
  Latino   0
  Asian   0
  Age (range)   28 – 64
  Age (mean and SD)   46,55 ± 14,2
  Normal Skin   10 (50%)
  Dry Skin   10 (50%)

table 1

Evaluation of cutaneous hydration

Skin hydration values increase statistically in all long-term tests. In the short test it returns to baseline levels after 24 h (table 2).

Pro Youth 2% in cream t0 t1h t24h t15d t30d
   Corneometric measurement 44,45 ± 8,48 53,67 ± 6,39 46,64 ± 4,84 52,48 ± 7,36 54,47 ± 6,47
   Baseline change from t0 (mean and SD)   9,22 ± 6,06 2,19 ± 9,50 8,03 ± 8,37 10,0 ± 11,8
   Percentage change from t0 (mean)   23,2 % 8,44 % 20,6 27,3 %
   p-value   0,000 0,316 0,000 0,001

table 2

Evaluation of TEWL

Application of the product significantly reduces the evaporation value of the cutaneous water, compared to the mean basal value, in the long term test (Table 3). This value decreases by 11% after 30 days of daily use.

Pro Youth 2% in cream t0 t1h t24h t15d t30d
   TEWL measurement 12,81 ± 2,94 12,69 ± 2,57 11,77 ± 2,17 11,25 ± 2,54 10,97 ± 2,71
   Baseline change from t0 (mean and SD)   -0,1 ± 2,49 -1,0 ± 2,92 -1,5 ± 3,11 -1,8 ± 3,88
   Percentage change from t0 (mean)   0,99 % -5,3 % -9,5 % -11,1 %
   p-value   0,839 0,130 0,037 0,048

table 3

Evaluation of skin elasticity

Changes in elastomeric measurements during the short and long term tests are show n in Table 4. During the study, the parameters R6 and R7 are improved in the long-term test after 30 days.

Pro Youth 2% in cream t0 t1h t24h t15d t30d
   R0 0,123 ± 0,06 0,110 ± 0,05 0,124 ± 0,07 0,144 ± 0,06 0,104 ± 0,04
   p-value   0,093 0,904 0,341 0,289
   R6 0,237 ± 0,16 0,271 ± 0,23 0,244 ± 0,18 0,209 ± 0,18 0,155 ± 0,09
   p-value   0,266 0,817 0,810 0,025
   R7 0,347 ± 0,10 0,376 ± 0,11 0,345 ± 0,07 0,358 ± 0,09 0,392 ± 0,08
   p-value   0,051 0,906 0,655 0,043

table 4

Consumer test

After the use of the product, the sample in question expressed mainly positive opinions to the questions asked and most of the interviewees gave an evaluation between “enough” and “a lot” (Table 5).

 

AFTER USE, TO WHAT EXTENT DO YOU CONSIDER THAT PRO YOUTH AT 2% CREAM IS a lot enough indifferent insufficient not at all
  easily absorbable 0% 85% 10% 5% 0%
  make your skin more hydrated 15% 55% 20% 10% 0%
  make your skin more nourished 10% 50% 35% 0% 5%
  make your skin more elastic 15% 45% 35% 5% 0%
  make your skin more supple 10% 70% 15% 5% 0%

table 5

Assessment of tolerability

None of the 20 volunteers had adverse or allergic adverse reactions.