All 20 subjects completed the study. The demographic characteristics of the sample are shown in table 1. All non-invasive tests were carried out by the same experimenter, between 10 and 14, at an average ambient temperature of 22 ° C and an average relative humidity of 57%.

   Characteristic Frequency
   n 20
   drop-out 0
   Male 8 (40%)
   Female 12 (60%)
   White 20 (100%)
   Black 0
   Latino 0
   Asian 0
   Age (range) 21 – 51
   Age (mean and SD) 32,35 ± 7,04

Evaluation of cutaneous hydration Skin hydration values increase statistically significantly in the Long Term Test (Table 2).

   MULTI FEEL® t0 t1h t7d t15g
   Corneometric measurement 36,61 ± 6,88 38,96 ± 5,83 40,29 ± 6,29 40,08 ± 6,25
   Baseline change from t0 (mean and SD)
  2,35 ± 7,92 3,68 ± 7,78 3,47 ± 6,56
   Percentage change from t0 (mean)
  9,73 % 12,8 % 11,8 %
   p-value   0,2005 0,048 0,0287

TEWL Evaluation

Both formulations determined a decrease in TEWL after 15 days of daily use (table 3).

   MULTI FEEL® t0 t1h t7d t15g
   TEWL measurement 13,82 ± 1,01 13,26 ± 1,67 12,91 ± 1,49 12,30 ± 1,80
   Baseline change from t0 (mean and SD)
  -0,5 ± 1,23 -0,9 ± 1,06 -0,9 ± 1,11
   Percentage change from t0 (mean)
  -4,1 % -6,6 % -7,02 %
   p-value   0,055 0,145 0,001

Colorimetry evaluation

The colorimetric values are reduced after 15 days of treatment (table 4).

   MULTI FEEL® t0 t1h t7d t15g
   Mexameter E measurement 299,9 ± 35,5 291,7 ± 34,8 279,0 ± 39,6 267,3 ± 41,0
   Baseline change from t0 (mean and SD)
  -8,2 ± 30,6 -20, ± 30,7 -24, ± 41,4
   Percentage change from t0 (mean)
  -2,2 % -6,6 % -7,72 %
   p-value   0,243 0,141 0,017