All 15 subjects completed the study and their demographic characteristics are reported in table 1. All the instrumental examinations were performed in the same clinic, at an average temperature of 22 ° ± 1.3 ° and at an average humidity of 58% ± 1.8%, between 9 and 14 in the morning. The measurements were always made by the same experimenter.

Demographic characteristics of the patients
                                                                      n = 15
Drop-out n = 0
Male 0 – 0%
Female 15 – 100%
Age (range) 31 – 60
Age (mean and SD) 42,4 ± 9,73

Colorimetric evaluation

After the application of the product, there has been a decrease in melanin level over time, reaching statistical significance after 30 days of use (table 2).

PG6 ACTIVE AA- BETC ® t0 t15d t30d
Colorimetric M measurement 391,8 ± 30,3 381,7 ± 26,5 372,8 ± 30,5
Baseline-adjusted difference (mean and SD)   -7,5 ± 18,7 -15,1 ± 31,7
percentage change mean from t0   -2,3 % -4,5 %
p-value   0,088 0,047

Dermatological evaluation with Scaling Severity Score

The results of the clinical examination show an improvement, compared to baseline, of the degree of pigmentation of the facial spots analyzed. This decrease approaches the statistical significance after 30 days (Table 3).

PG6 ACTIVE AA- BETC ® t0 t15d t30d
Clinical Scores (degree of pigmentation) 3,93 ± 0,70 3,66 ± 0,72 3,53 ± 0,51
p-value   0,104 0,082

Psychorheological test

After 30 days of application of the product the sample in question expressed mainlypositive judgments to the questions asked and most of the interviewees gave an evaluation between “enough” and “very” (Table 4).

PG6 ACTIVE AA- BETC ® very quite indifferent poor for nothing
after using the product, does the skin appear brighter? 20% 40% 27% 7% 7%
after using the product, the spots appear lighter? 40% 40% 7% 7% 7%