Our study aimed to evaluate the effectiveness of an active called PG6 ACTIVE AA- BET C ® .

This product, POLYGLYCERYL-6, AZELAIC ACID, BETAINE, has depigmenting properties not yet present in the medical literature. It is a derivative of azelaic acid whose depigmenting activity has already been demonstrated (Gunia-Krzy¿ak 2016). In our study we wanted to test the lightening efficacy of this product in a long term test.

The short term test is important, in the efficacy studies, because it could have a high discriminating power as it is possible to reach an improvement of the skin properties after a single application (Dal’Belo 2006). On the other hand, long-term studies are important for evaluating the real effects, on the superficial layers of the skin, determined by the functional principles present in the product (Prall 1986, Berardesca 1997).

In both types of tests, it is better to work with a sample of middle-aged volunteers in which the epidermis has more alterations.

For these reasons, we have investigated the lightening effect on a wide-range population with skin that has hyperchromic facial spots.

Measurement of efficacy was performed using the Mexameter probe, already approved internationally for the study of skin color changes, and subjective evaluations with clinical scores and psychorheological tests.

The interpretation of the results revealed that there are significant reductions in the degree of pigmentation of the facial skin spots after repeated application of the tested product. The skin colorimetry related to the parameter M (Melanin) is reduced after 30 days reaching a maximum average delta of -15%. The clinical score and the psycho-psychological test would seem to confirm these results.

The results obtained therefore show that this product shows a clearing effectiveness by confirming what has already been described by other authors regarding the effectiveness of its depigmenting principles.

These data should be confirmed with a broader statistical sample and comparison vs placebo.