Our study had the purpose of evaluating the moisturizing and soothing properties of PG6 Active HYDRA FACTOR® used at 2% in cream, containing various emollient and anti-inflammatory principles.In our study we wanted to test, in a short term test, the soothing efficacy, in a long term test, the moisturizing efficacy and tolerability.

The short term test is important, in efficacy studies, because it could have a high discriminating power as it is possible to achieve an improvement of skin properties after a single application (Belo 2006). Long term studies are instead important to evaluate the real effects on the surface layers of the skin, determined by the functional principles present in the product (Prall 1986, Berardesca 1997). In both types of tests, it is recommended to work with a sample of middle-aged volunteers in which the epidermis presents the greatest alterations. For these reasons, we carried out the study on a middle aged population. In this trial, we also used a combination of non-invasive and clinical techniques.

The interpretation of the results revealed that there are significant increases in hydration and an improvement in TEWL and Colorimetry after application of the product on skin artificially irritated by SDS.

Skin hydration increases statistically significant at all times studied, reaching values of +12% after 7 days and +14% after 14 days of daily use.

The soothing efficacy of the product was confirmed by a statistically significant reduction in TEWL of 9% and erythema of 17% after 8 hours of application of the product on a patch of skin irritation caused by SDS in skin occlusion for 4 hours.