SLS causes a significant disruption of the skin barrier resultant in an increase in TEWL values and in Erythema index.
Results – Soothing efficacy – HYDRO-B18
All the participants completed the trial. Here are the summarizing tables of values.
INDUCTION OF IRRITATION
SITE A: POSITIVE CONTROL
TIMING/PARAMETERS | MEAN | ST.DEV. | P-VALUE | SIGNIFICANCE |
T0 – TEWL | 12.6 | 4.26 | p<0.0001*** | yes |
T0 – EI | 252.35 | 47.78 | p<0.0001*** | yes |
SITE B: NEGATIVE CONTROL
TIMING/PARAMETERS | MEAN | ST.DEV. | P-VALUE | SIGNIFICANCE |
T0 – TEWL | 7.38 | 1.82 | p=0.004** | yes |
T0 – EI | 183.05 | 47.66 | p=0.9892 | yes |
TIMING | Δ% Site i/ Site A | P-VALUE | SIGNIFICANCE |
SITE D: HYDRO-B18® | |||
T0 | -1% | p=0.7660 | no |
T1 | -3% | p=0.6263 | no |
T2 | -17% | p=0.0110* | yes |
T3 | -21% | p=0.0094** | yes |
SITE E: BISABOLOL | |||
T0 | -1% | p=0.9569 | no |
T1 | 0% | p=0.9892 | no |
T2 | -9% | p=0.2339 | no |
T3 | -16% | p=0.0638 | no |
SITE F: AMMONIUM GLYCYRRHIZATE | |||
T0 | -2% | p=0.6071 | no |
T1 | -6% | p=0.5250 | no |
T2 | -16% | p=0.0315* | yes |
T3 | -14% | p=0.0638 | no |
An increase of the index of erythema after SLS application is detected up to 24 hours (site A, t1). The product interrupts the increase in erythema index (site C, t2 e t3) more than standard Bisabolol (site D), Ammonium Glycyrrhizate (site E).
TRANSEPIDERMAL WATERLOSS
TIMING | Δ% Site i/ Site A | P-VALUE | SIGNIFICANCE |
SITE D: HYDRO-B18® | |||
T0 | -1% | p=0.9784 | no |
T1 | 5% | p=0.7150 | no |
T2 | -16% | p=0.0119* | yes |
T3 | -9% | p=0.3647 | no |
SITE E: BISABOLOL | |||
T0 | 1% | p=0.6848 | no |
T1 | 4% | p=0.6949 | no |
T2 | -15% | p=0.0222* | yes |
T3 | -10% | p=0.2790 | no |
SITE F: AMMONIUM GLYCYRRHIZATE | |||
T0 | -2% | p=0.4091 | no |
T1 | -1% | p=0.7049 | no |
T2 | -14% | p=0.0167* | yes |
T3 | -11% | p=0.1848 | no |
The product reduces the transepidermal water loss (TEWL) (site C, t2) as the Bisabolol (site D,t2) and Ammonium Glycyrrhizate do (site E,t2).