The 20 subjects completed the study. The demographic characteristics of the sample are shown in table 1.
All non-invasive tests were carried out by the same experimenter at an average ambient temperature of 23 ° C and an average relative humidity of 55%.
All tests were performed in the morning between 10 am and 2 pm.

Evaluation of cutaneous hydration

Cutaneous hydration values increased statistically significantly at all times, both in the short and in the long term test (table 2).

Demographic characteristics of the patients
N = 20
Male 0 – 0%
Female 20 – 100%
Age (range) 43 – 61
Age (mean and SD) 52,1 ± 6,64
ANTIWRINKLES TOUCH ® at 4% t0 t30min t2h t7d t28d
Corneometric measurement 55,7 ± 8,31 69,65 ± 9,63 61,25 ± 8,97 63,05 ± 8,48 62,4 ± 10,5
Baseline change from t0 (mean and SD)   13,9 ± 14,0 5,55 ± 11,3 7,35 ± 13,0 6,7 ± 9,38
Percentage change from t0 (mean)   28,2 % 11,9 % 15,8 % 13,0 %
p-value   0,000 0,021 0,01 0,002

Assessment of cutaneous elasticity

Changes in elastomeric measurements during the short and long term test are shown in table 3.
In the short term test, changes are made by increasing only the parameter R6. In the long term test the parameters R6 and R7 increase over time and are statistically significant after 28 days.

ANTIWRINKLES TOUCH ® at 4% t0 t30min t2h t7d t28d
R0 0,058 ± 0,04 0,068 ± 0,04 0,060 ± 0,04 0,050 ± 0,02 0,056 ± 0,04
p-value   0,133 0,710. 0,379 0,915
R6 0,527 ± 0,20 0,637 ± 0,17 0,601 ± 0,17 0,554 ± 0,20 0,654 ± 0,11
p-value   0,025 0,081 0,399 0,017
R7 0,419 ± 0,05 0,461 ± 0,10 0,429 ± 0,09 0,450 ± 0,09 0,496 ± 0,14
p-value   0,17 0,723 0,218 0,044

Evaluation of cutaneous roughness

Some profilometric values change over time both in short and in long term test: the SEsm parameter reduces its values after 7 and 28 days, the SEsm parameter increases its values reaching statistical significance after 28 days.

ANTIWRINKLES TOUCH ® at 4% t0 t30min t2h t7d t28d
SEsc 0,747 ± 0,29 0,717 ± 0,25 0,723 ± 0,24 0,617 ± 0,16 0,545 ± 0,19
p-value   0,177 0,451 0,047 0,035
SEr 2,771 ± 1,15 2,492 ± 0,85 2,545 ± 0,93 2,604 ± 0,83 2,469 ± 0,72
p-value   0,052 0,15 0,157 0,079
SEw 69,16 ± 17,1 69,15 ± 14,8 66,46 ± 15,5 65,54 ± 16,7 63,20 ± 17,0
p-value   0,499 0,146 0,074 0,056
SEsm 108,6 ± 24,8 99,31 ± 41,4 111,6 ± 27,8 113,6 ± 35,0 122,9 ± 45,1
p-value   0,125 0,243 0,156 0,046

Scaling Severity Scores

The results of the clinical examination demonstrate a subjective reduction in roughness over time that approximates statistical significance after 30 days of use of the product.

ANTIWRINKLES TOUCH ® at 4% t0 t7d t30d
Scaling Severity Score 2,5 ± 0,51 2,45 ± 0,51 2,4 ± 0,50
p-value   0,16 0,08

Assessment of tolerability

None of the 20 volunteers had adverse or allergic adverse reactions.