ANTIWRINKLES TOUCH ® at 4% | t0 | t7d | t30d | |
Scaling Severity Score | 2,5 ± 0,51 | 2,45 ± 0,51 | 2,4 ± 0,50 | |
p-value | 0,16 | 0,08 |
Results – Efficacy test – antiwrinkles TOUCH®
The 20 subjects completed the study. The demographic characteristics of the sample are shown in table 1.
All non-invasive tests were carried out by the same experimenter at an average ambient temperature of 23 ° C and an average relative humidity of 55%.
All tests were performed in the morning between 10 am and 2 pm.
Evaluation of cutaneous hydration
Cutaneous hydration values increased statistically significantly at all times, both in the short and in the long term test (table 2).
Demographic characteristics of the patients | |
N = | 20 |
Male | 0 – 0% |
Female | 20 – 100% |
Age (range) | 43 – 61 |
Age (mean and SD) | 52,1 ± 6,64 |
ANTIWRINKLES TOUCH ® at 4% | t0 | t30min | t2h | t7d | t28d | |
Corneometric measurement | 55,7 ± 8,31 | 69,65 ± 9,63 | 61,25 ± 8,97 | 63,05 ± 8,48 | 62,4 ± 10,5 | |
Baseline change from t0 (mean and SD) | 13,9 ± 14,0 | 5,55 ± 11,3 | 7,35 ± 13,0 | 6,7 ± 9,38 | ||
Percentage change from t0 (mean) | 28,2 % | 11,9 % | 15,8 % | 13,0 % | ||
p-value | 0,000 | 0,021 | 0,01 | 0,002 |
Assessment of cutaneous elasticity
Changes in elastomeric measurements during the short and long term test are shown in table 3.
In the short term test, changes are made by increasing only the parameter R6. In the long term test the parameters R6 and R7 increase over time and are statistically significant after 28 days.
ANTIWRINKLES TOUCH ® at 4% | t0 | t30min | t2h | t7d | t28d | |
R0 | 0,058 ± 0,04 | 0,068 ± 0,04 | 0,060 ± 0,04 | 0,050 ± 0,02 | 0,056 ± 0,04 | |
p-value | 0,133 | 0,710. | 0,379 | 0,915 | ||
R6 | 0,527 ± 0,20 | 0,637 ± 0,17 | 0,601 ± 0,17 | 0,554 ± 0,20 | 0,654 ± 0,11 | |
p-value | 0,025 | 0,081 | 0,399 | 0,017 | ||
R7 | 0,419 ± 0,05 | 0,461 ± 0,10 | 0,429 ± 0,09 | 0,450 ± 0,09 | 0,496 ± 0,14 | |
p-value | 0,17 | 0,723 | 0,218 | 0,044 |
Evaluation of cutaneous roughness
Some profilometric values change over time both in short and in long term test: the SEsm parameter reduces its values after 7 and 28 days, the SEsm parameter increases its values reaching statistical significance after 28 days.
ANTIWRINKLES TOUCH ® at 4% | t0 | t30min | t2h | t7d | t28d | |
SEsc | 0,747 ± 0,29 | 0,717 ± 0,25 | 0,723 ± 0,24 | 0,617 ± 0,16 | 0,545 ± 0,19 | |
p-value | 0,177 | 0,451 | 0,047 | 0,035 | ||
SEr | 2,771 ± 1,15 | 2,492 ± 0,85 | 2,545 ± 0,93 | 2,604 ± 0,83 | 2,469 ± 0,72 | |
p-value | 0,052 | 0,15 | 0,157 | 0,079 | ||
SEw | 69,16 ± 17,1 | 69,15 ± 14,8 | 66,46 ± 15,5 | 65,54 ± 16,7 | 63,20 ± 17,0 | |
p-value | 0,499 | 0,146 | 0,074 | 0,056 | ||
SEsm | 108,6 ± 24,8 | 99,31 ± 41,4 | 111,6 ± 27,8 | 113,6 ± 35,0 | 122,9 ± 45,1 | |
p-value | 0,125 | 0,243 | 0,156 | 0,046 |
Scaling Severity Scores
The results of the clinical examination demonstrate a subjective reduction in roughness over time that approximates statistical significance after 30 days of use of the product.
Assessment of tolerability
None of the 20 volunteers had adverse or allergic adverse reactions.